March 19, 2023 2 min read

trans-Nerolidol, a naturally occurring sesquiterpene alcohol, has attracted attention for its diverse biological activities. This monograph aims to provide a comprehensive review of scientific studies related to the healing potential of trans-nerolidol, covering its sources, chemical properties, pharmacological activities, and therapeutic potential in various disorders.


trans-Nerolidol has been widely studied for its potential healing properties, including anti-inflammatory, antitumor, antimicrobial, and anti-parasitic activities. This review discusses the current scientific knowledge on trans-nerolidol and its potential therapeutic applications.

Sources and Chemical Properties

trans-Nerolidol is found in various plants, including tea tree, ginger, and jasmine. It is a sesquiterpene alcohol characterized by a 15-carbon skeleton with one hydroxyl group and three double bonds.

Pharmacological Activities

Anti-inflammatory Activity
trans-Nerolidol exhibits anti-inflammatory properties in both in vitro and in vivo studies. It has been shown to reduce the production of pro-inflammatory mediators such as nitric oxide (NO) and cytokines (Rodrigues et al., 2016).

Antitumor Activity
trans-Nerolidol has demonstrated antitumor effects in various cancer cell lines, including breast, lung, and colon cancer cells. It has been suggested to induce apoptosis and inhibit cell proliferation through multiple mechanisms, such as the modulation of cell signaling pathways and the induction of oxidative stress (Chen et al., 2013).

Antimicrobial Activity
trans-Nerolidol exhibits antimicrobial activity against various bacteria, fungi, and viruses, including Staphylococcus aureus, Escherichia coli, and Candida albicans (Bakkali et al., 2008).

Anti-parasitic Activity
trans-Nerolidol has demonstrated anti-parasitic effects against parasites such as Plasmodium falciparum and Leishmania spp. It has been suggested to interfere with the parasite's metabolism and disrupt its cell membrane (Lachenmeier et al., 2019).

Therapeutic Potential in Various Disorders

Inflammatory Disorders
The anti-inflammatory activity of trans-nerolidol has been explored for its potential use in treating various inflammatory disorders, such as arthritis, asthma, and colitis. Its ability to modulate the production of pro-inflammatory mediators may help alleviate inflammation and improve symptoms associated with these conditions (Rodrigues et al., 2016).

The antitumor effects of trans-nerolidol have been investigated for their potential use in cancer therapy. Its ability to induce apoptosis and inhibit cell proliferation may contribute to its antitumor properties, suggesting potential applications as an anticancer agent (Chen et al., 2013).

Infectious Diseases
The antimicrobial properties of trans-nerolidol make it a promising candidate for treating bacterial, fungal, and viral infections. Studies have demonstrated its effectiveness in inhibiting the growth of various pathogens and reducing the severity of conditions (Bakkali et al., 2008).

Parasitic Diseases
trans-Nerolidol's anti-parasitic effects have been explored for their potential use in treating parasitic diseases, such as malaria and leishmaniasis. Its ability to interfere with parasite metabolism and disrupt cell membranes may contribute to its anti-parasitic properties (Lachenmeier et al., 2019).

Trans-nerolidol has demonstrated various pharmacological activities contributing to its potential healing capabilities. Its diverse activities highlight the potential therapeutic applications of trans-nerolidol in multiple disorders, including inflammatory conditions, cancer, infectious diseases, and parasitic diseases. Further research is needed to elucidate the precise mechanisms underlying its pharmacological effects and establish optimal dosages, formulations, and routes of administration for clinical use. The potential of trans-nerolidol as an adjuvant therapy in combination with other medications should also be explored to maximize its therapeutic potential.

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