March 19, 2023 2 min read

Valencene, a naturally occurring sesquiterpene, has been investigated for its diverse biological activities. This monograph aims to provide a comprehensive review of scientific studies related to the healing potential of valencene, covering its sources, chemical properties, pharmacological activities, and therapeutic potential in various disorders.


Valencene, a sesquiterpene compound, has garnered interest for its wide range of biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. This review discusses the current state of scientific knowledge on valencene and its potential therapeutic applications.

Sources and Chemical Properties

Valencene is primarily found in the essential oils of various plants, such as citrus fruits, Valencia oranges, and some herbs. It is characterized by a 15-carbon skeleton and a unique tricyclic structure, which contributes to its distinct scent and flavor.

Pharmacological Activities

Antioxidant Activity

Valencene has demonstrated antioxidant properties in various in vitro studies, indicating its potential to scavenge free radicals and protect cells from oxidative stress (Ciftci et al., 2013).

Anti-inflammatory Activity

Valencene has been reported to exhibit anti-inflammatory effects, as demonstrated by its ability to inhibit the production of pro-inflammatory mediators and modulate the immune response (Chen et al., 2014).

Antimicrobial Activity

Valencene has shown antimicrobial activity against various bacteria and fungi, suggesting its potential use as a natural antimicrobial agent (Fyhrquist et al., 2018).

Therapeutic Potential in Various Disorders

Oxidative Stress-related Disorders

The antioxidant properties of valencene may have potential applications in the treatment of oxidative stress-related disorders, such as neurodegenerative diseases, cardiovascular diseases, and diabetes. Its ability to scavenge free radicals and protect cells from oxidative damage may help improve overall health (Ciftci et al., 2013).

Inflammatory Disorders

The anti-inflammatory activity of valencene has been explored for potential use in the treatment of various inflammatory disorders, such as arthritis, asthma, and inflammatory bowel diseases. By modulating the production of pro-inflammatory mediators, valencene may help alleviate inflammation and improve symptoms associated with these conditions (Chen et al., 2014).

Infectious Diseases

The antimicrobial activity of valencene suggests potential use in the treatment of bacterial and fungal infections. Studies have demonstrated its effectiveness in inhibiting the growth of various pathogens, potentially reducing the severity of conditions and contributing to faster recovery (Fyhrquist et al., 2018).


Valencene has demonstrated a range of pharmacological activities that contribute to its potential healing capabilities. Its diverse activities highlight the potential therapeutic applications of valencene in various disorders, including oxidative stress-related disorders, inflammatory disorders, and infectious diseases. Further research is needed to elucidate the precise mechanisms underlying its pharmacological effects and establish optimal dosages, formulations, and routes of administration for clinical use.

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