Sabinene, a naturally occurring bicyclic monoterpene, has gained attention for its diverse biological activities. This monograph aims to provide a comprehensive review of scientific studies related to the healing potential of sabinene, covering its sources, chemical properties, pharmacological activities, and therapeutic potential in various disorders.
Sabinene is a bicyclic monoterpene with various biological activities, including antioxidant, antimicrobial, and anti-inflammatory properties. This review discusses the current state of scientific knowledge on sabinene and its potential therapeutic applications. Sources and Chemical Properties
Sabinene is found in various plants, including black pepper, cardamom, and the essential oils of several citrus fruits. It exists in two stereoisomeric forms: (−)-sabinene and (+)-sabinene. A 10-carbon skeleton characterizes Sabinene with a bicyclic structure and one double bond. Pharmacological Activities
Sabinene exhibits antioxidant properties, as demonstrated by its ability to scavenge free radicals and reduce oxidative stress in various in vitro and in vivo models (Yildirim et al., 2015).
Sabinene has demonstrated antimicrobial activity against various bacteria and fungi, including Staphylococcus aureus, Escherichia coli, and Candida albicans (Bouchra et al., 2003).
Sabinene has shown anti-inflammatory effects in both in vitro and in vivo studies by inhibiting pro-inflammatory mediators such as nitric oxide (NO) and cytokines (Da Silva et al., 2012). Therapeutic Potential in Various Disorders
Oxidative Stress-related Disorders
The antioxidant properties of sabinene may have potential applications in treating oxidative stress-related disorders, such as neurodegenerative diseases, cardiovascular diseases, and diabetes. Its ability to scavenge free radicals and reduce oxidative stress may help protect cells and tissues from damage and improve overall health (Yildirim et al., 2015).
The antimicrobial activity of sabinene suggests potential use in treating bacterial and fungal infections. Studies have demonstrated its effectiveness in inhibiting the growth of various pathogens, potentially reducing the severity of conditions and contributing to faster recovery (Bouchra et al., 2003).
The anti-inflammatory activity of sabinene has been explored for potential use in treating various inflammatory disorders, such as arthritis, asthma, and inflammatory bowel diseases. Its ability to modulate the production of pro-inflammatory mediators may help alleviate inflammation and improve symptoms associated with these conditions (Da Silva et al., 2012).
Sabinene has demonstrated a range of pharmacological activities that contribute to its potential healing capabilities. It highlights the potential therapeutic applications of sabinene in various disorders, including oxidative stress-related disorders, infectious diseases, and inflammatory disorders. Further research is needed to elucidate the mechanisms underlying its pharmacological effects and establish optimal dosages and routes of administration.