March 19, 2023 3 min read

Myrcene is a prominent monoterpene found in various plants, including cannabis, hops, and lemongrass, with a growing body of research supporting its therapeutic potential. This monograph reviews the current scientific literature on the healing properties of myrcene, focusing on its potential applications in pain relief, anti-inflammation, anxiety reduction, and sleep improvement. The possible side effects and limitations of myrcene are also discussed, as well as directions for future research.


Myrcene (7-methyl-3-methylene-1,6-octadiene) is a naturally occurring monoterpene widely found in plants, including Mangos, Cannabis sativa, Humulus lupulus (hops), and Cymbopogon citrates (lemongrass). Terpenes are organic compounds responsible for the aroma and flavor of plants and have been utilized for centuries in traditional medicine. Myrcene is known for its earthy, musky aroma and is a key component in the fragrance and flavor industries. This monograph examines the scientific evidence supporting the healing potential of myrcene, delving into its applications in pain relief, anti-inflammation, anxiolytic effects, and sleep improvement.

Analgesic and Anti-inflammatory Effects

Multiple studies have demonstrated the analgesic and anti-inflammatory properties of myrcene. In a da Silva et al. (2021) study, myrcene showed significant antinociceptive and anti-inflammatory effects in mice. Myrcene could be a potential candidate for developing new analgesic and anti-inflammatory drugs. Another survey by Rufino et al. (2015) demonstrated that myrcene effectively inhibited the production of nitric oxide, a pro-inflammatory mediator, in murine macrophages. Myrcene may have the potential to treat inflammatory diseases.

Anxiolytic Effects

There is growing evidence suggesting that myrcene may possess anxiolytic properties. Galdino et al. (2012) found that myrcene exhibited anxiolytic-like effects in mice using the elevated plus maze and the light-dark box tests. These findings imply that myrcene could have potential applications in managing anxiety disorders.

Sleep Improvement

Myrcene has long been associated with sedative effects, particularly in traditional medicine. In a study by Vale et al. (2002), myrcene increased sleeping time in mice, suggesting its potential as a sleep aid. In another study, Klocke et al. (2017) reported that myrcene modulated sleep duration and architecture in Drosophila melanogaster, further supporting its sleep-enhancing properties.

The existing scientific literature on myrcene supports its potential as a versatile therapeutic agent, particularly for pain relief, anti-inflammation, anxiety reduction, and sleep improvement. However, further studies must validate these findings in human subjects and determine the optimal dosage and administration methods. Future research should also explore the potential synergistic effects of myrcene with other terpenes and cannabinoids and its interactions with other medications.

Potential Applications in Medicine and Therapeutics

As more research is conducted on myrcene, its potential applications in medicine and therapeutics could become more evident. Some possible areas of exploration include:

7.1. Chronic Pain Management: Given its analgesic properties, myrcene could be studied as a potential alternative or adjunct treatment for chronic pain management.

7.2. Inflammatory Conditions: Myrcene's anti-inflammatory effects suggest that it may have potential applications in treating inflammatory conditions, such as arthritis, inflammatory bowel disease, and autoimmune disorders.

7.3. Anxiety Disorders: With its anxiolytic properties, myrcene could be explored as a potential treatment option for various anxiety disorders, including generalized anxiety disorder, social anxiety disorder, and panic disorder.

7.4. Sleep Disorders: Myrcene's sleep-enhancing properties may be of interest in developing treatments for sleep disorders, such as insomnia and sleep apnea.

Regulatory Considerations and Safety

As the therapeutic potential of myrcene becomes more evident, regulatory bodies will need to establish guidelines for its use in medicine. This includes determining appropriate dosages, ensuring product quality and consistency, and identifying potential drug interactions. Additionally, the safety profile of myrcene should be further investigated, focusing on minimizing side effects and establishing contraindications for specific populations.

Myrcene is a versatile terpene with promising healing potential in various areas, including pain relief, anti-inflammation, anxiety reduction, and sleep improvement. As scientific research unveils its therapeutic properties, the medical community may incorporate myrcene into various treatment strategies. However, further investigation is needed to fully understand its mechanisms, potential side effects, and optimal usage in human subjects.

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