March 19, 2023 2 min read

Cadinene, a naturally occurring sesquiterpene, has demonstrated diverse biological activities in various studies. This monograph aims to provide a comprehensive review of scientific studies related to the healing potential of cadinene, covering its sources, chemical properties, pharmacological activities, and therapeutic potential in various disorders.


Cadinene is a sesquiterpene with a characteristic woody and earthy aroma. It has been recognized for its potential healing properties, including anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. This review discusses the current state of scientific knowledge on cadinene and its potential therapeutic applications.

Sources and Chemical Properties

Cadinene is found in various plants, including Eucalyptus, Juniperus, and Copaifera genera species. Its chemical structure features a fused tricyclic ring system, distinguishing it from other terpenes. There are two main isomers of cadinene: α-cadinene and β-cadinene.

Pharmacological Activities

Anti-Inflammatory Activity

Cadinene has been studied for its anti-inflammatory properties. In vitro and in vivo studies have demonstrated its ability to inhibit the production of pro-inflammatory mediators, such as nitric oxide (NO), prostaglandins, and cytokines (Lee et al., 2016).

Antimicrobial Activity

The antimicrobial properties of cadinene have been shown against a wide range of bacteria and fungi, including Staphylococcus aureus, Escherichia coli, and Candida albicans (de Oliveira et al., 2015). Its mechanism of action is believed to involve the disruption of microbial cell membranes, leading to cell death.

Antioxidant Activity

Cadinene has been reported to exhibit antioxidant activity by scavenging free radicals and reducing oxidative stress. Its antioxidant potential has been attributed to its ability to donate hydrogen atoms and chelate metal ions (Mourey et al., 2012).

Anticancer Activity

Cadinene has shown potential anticancer activity in various in vitro and in vivo studies. Its anticancer mechanisms are thought to involve the induction of apoptosis, cell cycle arrest, and inhibition of tumor angiogenesis (Zhang et al., 2018).

Therapeutic Potential in Various Disorders

Respiratory Disorders

Cadinene’s anti-inflammatory and antimicrobial properties have been explored for treating respiratory disorders, such as asthma, bronchitis, and sinusitis. Cadinene has been shown to reduce airway inflammation and improve lung function in animal models of asthma (Lopes et al., 2013).

Gastrointestinal Disorders

Cadinene has demonstrated gastroprotective effects in animal models of gastric ulcers. Its anti-inflammatory and antioxidant activities are believed to contribute to the healing of gastric mucosal lesions (de Souza et al., 2012).

Skin Disorders

Cadinene’s antimicrobial and anti-inflammatory properties make it an attractive candidate for treating skin disorders such as acne, eczema and wound healing. Its soothing and regenerative effects on skin tissue have also been reported (Nogueira et al., 2014).


The anticancer activity of cadinene has been investigated in various cancer types, including breast, lung, and colon cancer. Its potential as an adjuvant therapy in combination with conventional cancer treatments has also been explored (Zhang et al., 2018).

In conclusion, cadinene has demonstrated various pharmacological activities, including anti-inflammatory, antimicrobial, and antioxidant.

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